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Tamm horsfall protein
Tamm–Horsfall protein (THP) or uromodulin (gene name UMOD) is a 90-kDa protein produced almost exclusively in the kidney by the epithelial cells lining the thick ascending limb (TAL) of the loop of Henle and early distal tubules [ 1–3 ]. Urinary excretion occurs by proteolytic cleavage of the large ectodomain of the glycosyl phosphatidylinositol-anchored counterpart exposed at the luminal cell surface of the thick ascending limb of Henle's loop. Tamm-Horsfall Urinary Mucoprotein—Role in Renal Tubular Blockage by Casts.
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